Standard of Care sensibility: Anti-PD1 = no / Anti PDL1 = no (12,5 mg/kg)
FO cells
Mouse FO cells were created by self-fusing Sp2/0 myeloma cells using Sendai virus. They grow in a BALB/C background.
Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of BALB/C mice. The resulting tumours were monitored by measuring two diameters with calipers and extrapolating the volume to a sphere.
The mice bearing CT26 tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral, or subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1: (View PDF)
Tumour growth curve of the FO cells as subcutaneous tumours
Mean ± SEM (n=3; take rate 100%)
Drug Responses
Anti-PD1 12.5 mg/kg → No Response
Anti-PDL1 12.5 mg/kg → No Response