Tumour model

ES-Moult

Mantle cells lymphoma
XenograftIn vitro

ES-moult cells

Human Granta cells were isolated from a patient with non-hogkin’s lymphoma

Tumour growth in vivo

The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of SCID-CB17 mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.
The mice bearing ES-moult tumours can be treated by intra-peritoneal, intra-venous, intratumoral or subcutaneous injection of the compounds. Per os administration is also possible.

Figure 1: (View PDF)

Tumour growth curve of the ES-moult cells as xenograft Mean ± SEM (n=3; take rate 100%)

Antineo can also perform an intra-medullar implantation.

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Model characteristics

Organism
Human
Tissue of origin
B cells
Pathology
Mantle cells lymphoma
Model type
In vitro, Xenograft
Availability
Off the shelf (time of expansion)

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