Standard of Care sensibility: Anti-PD1 = no / Anti PDL1 = no (12,5 mg/kg).
CT26 cells
Mouse CT26 cells were isolated from a NNMU induced undifferentiated colon carcinoma in a BALB/C mouse.
Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of BALB/C mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.
The mice bearing CT26 tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral or subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1: (View PDF) Tumour growth curve of the CT26 cells as subcutaneous tumours
Mean ± SEM
Antineo can also perform an orthotopic intra-caecal implantation.
Drug Responses
Figure 2: (View PDF) Tumour growth curve of the CT26 cells as subcutaneous tumours
Mean ± SEM (n=4)
Anti-PD1 12.5 mg/kg à No Response
Anti-PDL1 12.5 mg/kg à No Response
Immunophenotyping data of the lymphoid and myeloid lineage are available upon request.