Standard of Care sensibility: Trastuzumab = yes.
A549 cells
Human A549 cells were isolated from the lung of a patient with lung carcinoma.
Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of SCID-CB17 mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.
The mice bearing A549 tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral or subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1: (View PDF)
Tumour growth curve of the A549 cells as xenograft. Mean ± SEM
Standard-Of-Care Drug Responses
Figure 2: (View PDF)
Response of A549 to Trastuzumab treatment (25 mg/kg, biweekly)
Mean ± SEM (n=3 per group)