Tumour model

MeWo

Malignant melanoma
XenograftIn vitro

MeWo cells

Human MeWo cells were isolated from the lymph nodes of a patient with metastatic malignant melanoma.

Tumour growth in vivo

The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of SCID-CB17 mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.
The mice bearing MeWO tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral or subcutaneous injection of the compounds. Per os administration is also possible.

Figure 1: (View PDF)
Tumour growth curve of the MeWo cells as xenograft Mean ± SEM (n=10; take rate 90%)

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Model characteristics

Organism
Human
Tissue of origin
Skin
Pathology
Malignant melanoma
Model type
In vitro, Xenograft
Availability
Off the shelf (time of expansion)

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