DEL cells
Human DEL cells were isolated from a pleural effusion of a patient with malignant histiocytosis.
Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of NSG mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.
The mice bearing DEL tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral or subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1: (view PDF) Tumour growth curve of the DEL cells as subcutaneous tumors. Mean ± SEM (n=3
Luciferase model in vivo
Antineo has developed a DEL luciferase positive cell line for tumor growth follow-up with a luminescence imager (IVIS Lumina). The cells were implanted subcutaneously in 3 mice (10 x 106 cells).
Figure 3: (view PDF) Bioluminescent signal of DEL cells for Mouse 2
Figure 4: (view PDF) Bioluminescent signal of DEL cells for Mouse 3 (primary tumor and metastasis)